MISA was founded in Portland, Oregon in 1988. A group of government program managers, sign vendors, hospitality businesses and other met to network, share program ideas, and encourage consistency of practice. At least twenty states were represented. Within three years, state tourism industry leaders joined and the head office was established in Shawnee, Oklahoma. Within five years, two Canadian provinces were active members.

In 2005, the national headquarters returned to Oregon, managed from the office of the Oregon Travel Information Council.

MISA continues to meet annually to hear updated news of travel related programs. MISA represents its members at the federal level- ensuring that our voice is heard when federal policy is being considered.